※All efficacy descriptions on this website are based on research papers and clinical measurements, and do not involve personal efficacy. Please do not use it for medical purposes!
NMN FAQ
What is NMN? For in-depth understanding, please click the magic NMN
NMN is the most novel anti-aging health food at present. It is the first serious scientific research achievement in the world that has been rigorously scientifically verified to significantly reverse aging and prolong life. The market price is very high and counterfeit products are full, so it needs to be purchased and used with caution.
What is the effect of NMN?
In animal experiments, it was found that eating NMN may have anti-aging and life-extending effects. For in-depth understanding, please click the magic NMN
Where can I buy NMN in Taiwan?
Because the raw material of NMN is still too novel, there are not many relevant regulations in Taiwan at present, and in Taiwan's regulations, NMN is not registered as a food or drug, so neither food factories nor pharmaceutical factories can produce NMN. this product. Therefore, the truly purified NMN health food can only be purchased from abroad (purchased on behalf of others) or through cross-border e-commerce . Taiwan is not allowed to manufacture NMN.
In particular, Taiwan is not mature for NMN extraction and manufacturing technology. Taiwanese manufacturers are likely to buy impure NMN. Instead, add "cauliflower extract", "avocado extract", yeast powder and other similar extracts, and even buy non-purified NMN. NMN ingredients are fakes, so you need to enrich NMN related knowledge, so you are not easy to be deceived!
In addition to sufficient NMN knowledge, this website also organizes how to choose NMN brands, all of which have been rigorously evaluated, and the world's NMN No. 1 is strictly selected. It is the best learning website for NMN Taiwan. How does NMN choose a brand? Please click here for the NMN Buying Guide.
Foods that contain NMN?
NMN is a vitamin B3 (or nicotinic acid) derivative. Exist in cauliflower, Chinese cabbage, avocado, tomato, beef, shrimp, etc., but its concentration is very low.
Are NMN and Vitamin B3 the same?
NMN is a vitamin B3 derivative, but not exactly vitamin B3 because it has phosphates that affect its ability to enter its cells.
Is NMN an anti-aging health food?
In some studies on longevity, an ingredient: NMN (beta-nicotinamide mononucleotide) has been used to simulate the process of cellular aging and anti-aging.
NMN is a derivative of vitamin B3, which is actually a substance in natural foods, such as cauliflower, Chinese cabbage, avocado, tomato, beef, shrimp and so on.
Because it was found in animal experiments that NMN is related to the metabolic enzymes of cell aging, and may have anti-aging and life-extending effects. In foreign countries, NMN health food is very popular. Although the unit price often exceeds NT$10,000 and the price is very high, it is still very popular.
In Taiwan, more people have begun to show interest in NMN, a novel anti-aging health food.
The research background of NMN?
To explain NMN, we must first introduce "Sirtuins" and "NAD +"
About 20 years ago, an MIT biology professor and his team discovered a key gene "Sirtuins" in yeast that affects lifespan. And found that Sirtuins can participate in cellular metabolism and regulate the lifespan of lower organisms such as flies and bugs. Also in mammals, seven Sirtuins genes were found.
However, to activate this anti-aging gene requires the participation of "NAD +".
NAD+ appears in all middle school natural science textbooks because it is one of the molecules important for maintaining basic metabolism. However, NAD + cannot be directly supplemented, but NAD + is synthesized in the body by NMN, tryptophan and other ingredients.
Some theories suggest that NAD+ levels decline with age, and that NAD+ levels in the body at 50 are about half of what they were at 20, and the decline in NAD+ interferes with the ability of Sirtuin cells to slow down aging. ( Why does NAD+ decrease with age? Click here for this anti-aging study )
NMN is a derivative of vitamin B3 (niacin) and can be obtained from diet such as fruits, milk and vegetables.
Possible efficacy of NMN? ( For in-depth understanding of NMN, please click the magic NMN )
NMN According to the current research basis, it can be concluded that NMN may have the following effects:
Anti-vascular aging, increase muscle endurance and muscle strength, reduce the risk of heart disease, reduce the risk of Alzheimer's, reduce the risk of obesity, various chronic diseases, protect DNA sequence, improve the function of granulocytes and glands, promote stem cell function , maintain youthful vitality, healthy and longevity .
Side effects of NMN, are there any side effects of using NMN? (side effect) Is it safe to take NMN?
NMN is a natural small molecular substance that exists in the human body. Many foods such as cauliflower and edamame also contain a small amount of NMN. Since it is a natural substance, of course, it will not have side effects, and after long-term rigorous scientific verification, no side effects have been found. A number of human clinical trials in research institutions around the world continue to progress over time. In Japan in 2020, the latest NMN clinical trial has been published, testing 10 healthy men, consuming 100 to 500 mg of NMN, and observing possible side effects after 5 hours. Except for a slight increase in serum bilirubin, and a slight decrease in serum creatinine, chloride, and blood sugar, no side effects were found to be caused by consuming NMN . (link to clinical paper)
More human clinical verifications of the latest safety and efficacy of NMN have also been published. For example , on April 22, 2021, Washington University School of Medicine published a human clinical trial in the journal Science , targeting people with diabetes aged 55 to 75. Preliminary female, small clinical double-blind trial: 13 of the women in the clinical study received 250 mg of NMN orally daily for 10 weeks, and 12 received an ineffective placebo daily for the same period as a control group. There are the following 3 conclusions
1. Improve the metabolism of middle-aged and elderly women with prediabetes. (Can lose fat)
2. Promote muscle function and growth. (Can build muscle)
3. Prevent various diseases related to age. (Can prevent chronic diseases)
At the same time, this human clinical test also confirmed that NMN has no side effects . For details, please refer to NMN News! (Please click NMN News)
Where to buy NMN in Taiwan?
Now NMN is a raw material that is too novel, so there are not many relevant regulations in Taiwan at present, and in Taiwan's laws, NMN is not registered as a food or drug, so neither food factories nor pharmaceutical factories can produce NMN. item product.
Where should NMN be bought from?
At present, the production technology of NMN health food is leading the world in the United States. It is recommended to buy NMN imported from the United States.
What should I pay attention to when buying NMN ? How does NMN choose a brand? Just reading this is enough .
1. Before purchasing NMN products, you must recognize the content of NMN !
Due to the imperfection of Taiwan's regulations, the "brand name labeling" of NMN as a raw material cannot be managed. Therefore, there are many product names on the market with the big "NMN", but in fact, there is no NMN in the ingredients. These products sold on the market are replaced by the addition of "cauliflower extract", "avocado extract" and other similar extracts. Although these ingredients contain NMN, the content is so small that it cannot be compared with purified NMN products.
2. Many products are marked with NMN, but they are not added at all! The difference from the first point above is that: the first point is to exploit the loopholes in the regulations; the second point, the direct violation of the "Food Safety Management Law - Article 22" can be punished with a maximum fine of 4 million yuan.
Even if many products do not contain NMN at all, they are still labeled as containing this ingredient, which obviously misleads consumers to buy. In addition to violating the above-mentioned food safety management law, if it involves affecting human health, it will also involve criminal responsibility, fixed-term imprisonment and a fine.
As long as you see "Made in Taiwan" and "Ingredient Labeling: NMN" (not labeling cauliflower, other plant extracts, but directly labeling NMN), it is a direct violation of the law.
Health foods produced in Taiwan must comply with Taiwan's regulations. The raw material of NMN is not listed as any food or drug raw material, so whether it is intentional or unintentional, it can be inferred that there is a high probability that it has violated the law.
3. When purchasing NMN products, you must recognize the purity and activity of NMN ! Many NMN products on the market dare not write about the purity or activity of NMN, let alone have a purity certificate. It is recommended to purchase genuine NMN with a purity certificate. In particular, when purchasing, be sure to recognize the ingredient label on the bottle , and not just read the instructions on the Internet, so as not to buy counterfeit products.
4. When purchasing NMN products, you must recognize whether the products have FDA certification ! At present, the production technology of NMN health food is leading the world in the United States. It is recommended to buy NMN imported from the United States and certified by the US FDA. It is better if there are GMP good manufacturing practices or certifications such as cGMP and NFC natural food.
5. The addition of resveratrol to NMN products is even more powerful! According to Professor David Sinclair of Harvard University, NMN works best when paired with resveratrol, NMN provides fuel for the longevity gene Sirtuins; resveratrol activates Sirtuins independently. A combination of the two is more effective than a single formula. Harvard professor David Sinclair believes that if the longevity gene is regarded as a car, then NMN is the fuel of the car, and resveratrol is the accelerator pedal, both of which are indispensable.
6. When purchasing NMN products, the product manufacturing technology is also very important! NMN production technology is related to the absorption rate in the human body after taking it. At present, the latest process technology leads the world in the Nobel Prize-winning enzyme-directed evolution technology, SPT synthase technology, and RNA biocatalysis technology.
7. If NMN is selected into the products recommended by the <American Physicians' Medication Guide PDR >, it will have absolute guarantee, because to be selected into the PDR, 3 must be done:
(1) The product must be truly effective
(2) It must be manufactured with pharmaceutical grade standards
(3) The nutrients must be decomposed and absorbed within 45 minutes
Further reading: Why is it so important for NMN to have PDR certification?
What are Sirt 1~7, 7 longevity genes? ( For more information on longevity genes, please click Anti-aging Research )
SIRT1: Repair DNA and Arteries
SIRT2: Reduce Body Fat and Oxidative Response
SIRT3: Extending life
SIRT4: suppresses tumors and aids autophagy
SIRT5: Reduces fatty acid and oxidative reactions in the liver
SIRT6: Regulate blood sugar and reduce insulin resistance
SIRT7: Protect the heart
Many stem cell-related health products on the market claim to be able to restore youth. What is the difference between NMN and these stem cell health foods ?
All kinds of stem cell products are mixed, and there are indeed some good products, but NMN can be said to be a higher-level product, the reason is that the research conclusion of the 2019 Nature sub-journal paper: NMN is edible stem cells, which can promote various stem cell functions for health life extension. More importantly, NMN can not only promote stem cell function, but also activate Sirtuins1~7 longevity genes, repair the DNA of the whole body cells and activate the mitochondria of the whole body cells. It can be said to be the most natural, safe and effective anti-aging, high-tech product. It is the most recommended health food by authoritative research institutes.
What is Homeopathy ?
It is a natural therapy that constructs the required environment, starts a process with the smallest dose of medicine, stimulates the body's self-healing ability, and promotes the body's self-healing system to be in the best state. The treatment of diseases is mainly based on radical methods.
What is cross-border e-commerce ?
Cross-border e-commerce refers to an international business activity in which buyers and sellers conduct transactions and payments through online e-commerce platforms or self-operated official websites in different countries, and transport goods through cross-border logistics. It is currently the most mainstream business activity. trend . To put it simply, cross-border e-commerce means that companies can sell goods directly in the region to other countries without having to set up overseas.
Cross-border e-commerce is currently the most mainstream business model in the world, and it is also a trend that has formed. The Taiwan government has also seen this general trend, and the Legislative Yuan has also accelerated the review of relevant regulations. At present, cross-border e-commerce is legal in Taiwan, but relevant regulations It is not very perfect, it is still under review, please click here to learn about Taiwan's cross-border e-commerce regulations!
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How do NMN prices compare?
To initially evaluate the quality of NMN, we must first look at the purity, content and activity of NMN. Therefore, to compare NMN prices, it only makes sense to compare them on the same benchmark. First of all, don't compare with NMN purchased in Taiwan, because it is now mid-January 2022. So far, no Taiwan brand has been found to sell NMN with real high purity and high activity!
Take a closer look at the NMN sold in Taiwan, and some have a big "NMN", but when you look closely, there is no NMN in the ingredients at all. Instead, add "cauliflower extract", "avocado extract", yeast powder and similar extracts. Although these ingredients contain NMN, the content is very small, and there is no indication of NMN content and purity, which cannot be compared with purified NMN products.
From NMN benchmark 1 to later, due to the complex factors such as compound prescription, unilateral, activity, conversion rate, etc., these factors can be temporarily excluded, and it is simply converted into unit NMN price for comparison, and then comprehensive judgment is made after a bottom. For example: Assuming that a bottle of 30 capsules of NMN is priced at 4,000 yuan per capsule of 300mg, then each 1mg of NMN=4000/30/300=0.44 yuan
Of course, the price of NMN is only one of the reference items, the most important thing is the efficacy and quality!
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Can NMN be used for chronic patients such as diabetes?
April 22, 2021 Washington University School of Medicine, in the journal Science, publishes a small clinical double-blind trial in women with prediabetes between the ages of 55 and 75: a group of women in the clinical study received daily 250 mg of NMN was administered orally and the other group received a placebo for 10 weeks. Human clinical results have shown that NMN can increase muscle sensitivity to insulin, improve metabolism, and lower blood sugar . At the same time, it can also promote muscle function and growth , and effectively achieve the effect of increasing muscle and reducing fat, so diabetic patients are also suitable for using NMN (for detailed research, please click - the magical NMN )
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Can NMN boost autoimmunity against viruses and cancer?
On September 27, 2021, Okumura and other scientists from Juntendo University in Japan, published in Biomedical Research, confirmed that NMN can effectively enhance the activity of NK cells and increase the ability of cells to naturally kill cancer cells without increasing the number of NK immune cells. . Improve immunity, achieve the effect of fighting and preventing virus infection and cancer . Click here for detailed research
NK cells are a kind of human immune cells, which are called natural killer cells (Natural killer cells, NK), which belong to the vanguard of the immune system. NK does not need to receive special instructions from the immune system, nor does it need the cooperation of other cells, it can recognize and eliminate aging, tumor or virus-infected cells by itself. Many of today's very expensive cancer cell therapies use autoimmune NK cell therapy.
Although this study is not a human clinical test, more and more human clinical trials have confirmed that the benefits of NMN in mice can be transferred to humans. Therefore, it is believed that a related human test report will be published soon.
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How is NMN taken? How much NMN should I take every day?
Regarding the optimal daily dosage of NMN, based on the current (October 2021) clinical measurements of all human beings in the world, the range is from 100mg to 1200mg per day (2020 Irie.. et al., 2021 Liao.. et al., 2021 Yoshino.. et al), the measured results have no adverse effect on various physiological data of the human body such as temperature, blood pressure, cerebral blood flow, blood data or other forms of toxicity, etc., confirming that it can be administered safely and effectively metabolized in the body without any side effects . And according to the clinical measurement results, the larger the amount of use, the more obvious the effect of the experimental data. Therefore, it is recommended that the daily dosage of NMN can be 100mg to 1200mg per day according to different conditions such as individual age and body !
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How is NMN taken? When should NMN be taken daily?
When is the best time to take daily NMN? According to the operation of the human body's biological clock, it is recommended to take NMN in the wake-up phase of the biological clock in the morning . But there are too many brands of NMN, there are various formulas, and the mechanism of action is different, so should it be taken before or after meals? It is more appropriate to take it according to the recommended time of each brand.
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How is NMN taken? At what age do you start taking NMN?
The NAD+ level of the human body gradually decreases with age, which leads to aging. At the age of 50, the NAD+ level is only half of that at the age of 20. Therefore, even if you start taking it at the age of 30, although you may not feel obvious, you can still achieve the effect of preventing aging. Many celebrities look very young even though they are 5 or 60 years old. This is the effect of early maintenance! Since NMN is a cross-century anti-aging health food that has only appeared in recent years, it is recommended to start taking it when the physiological age begins to decline, especially for middle-aged and elderly people, and it is even more necessary for people to take it !
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What is the content of NMN in natural food? Can only eating natural food supplement enough NMN in the human body?
NMN exists in the human body and natural food. There are about 50 mg of NMN in human red blood cells. The content of NMN per 100 grams in natural food is shown in the table below, and the content is very low. Assuming that you want to supplement 300mg of NMN per day, the amount of food you need to eat is as shown in the table, 26.8-120 kg of cauliflower or 71.4-500 kg of beef. It does not meet the actual situation of daily diet at all, so it is necessary to supplement purified NMN to meet the needs of the body and increase the level of NAD+ in the human body.
Why is the health and longevity industry a future world trend industry? ( For more details on NMN industry trends, please click Anti-aging Research )
The aging of the global population is an irreversible trend. The health and longevity industry is the mainstream industry in the future, and it has become a fact. The world's richest people such as Li Ka-shing, Buffett, Bezos, etc., have invested large sums of money one after another. This is a major trend affecting all industries in the 21st century. - -Health and longevity industry ! It is estimated that the health and longevity industry market will reach 600 billion US dollars in the next 10 years. Especially after the Covid-19 epidemic and the advent of the post-epidemic era, autoimmunity will be the best way to fight the virus , so the health industry will develop more vigorously . Jack Ma also said: The next richest man will appear in the field of health and longevity. In particular, the cross-century health and longevity revolution of NMN is the focus of the mainstream trend. (September 2021, the world's richest man Bezos invests in the longevity industry latest news)
In the face of post-epidemic life, improving immunity is the key, especially the latest mutant virus Omicron is coming, are you ready? Don't worry, NMN will be your fastest, safe and effective secret weapon!
Going back to the best state when you were young, age-freezing and anti-aging is no longer an unreachable dream. You can also enjoy the magical technology of NMN as easily as the rich!
Traditional direct selling has declined, and cross-border e-commerce is the trend. With NMN's latest blue ocean market, it will detonate the biggest business opportunity in this century! No matter where you are in the world or what language you are in, you can have it right away with just a few simple steps online or in person!
The gap in information in the 5G era is the gap between health and wealth! If you don't keep up with the trend, you will be abandoned by the trend. Instead of having doubts in your heart, it is better to act now to create change!
There are so many NMN brands on the market, NMN evaluation, NMN efficacy, how to fully evaluate?
Because NMN's efficacy and research results are too powerful, it has the opportunity to replace most of the health food products on the market, so many unscrupulous industry players, in the name of NMN, but sell products that do not contain NMN ingredients, because NMN health food is still too new. , NMN has no regulations in Taiwan, causing many people to be deceived. Therefore, when evaluating NMN and choosing an NMN brand, you really need to evaluate carefully. There are many precautions. Be sure to enrich your professional knowledge and confirm it clearly. The NMN No1 website strictly selects the recommended brands, and the compound NMN products recommended by the most credible American Physician's Medication Guide, PDR , will check for you and provide a comprehensive guarantee. One of the most reliable options. To know the NMN brand, please click this link
NMN is so amazing, I really want to experience what it feels like to see pure NMN?
Here's your chance! In order to celebrate the establishment of the official account of the "Being Younger" line, just click the button below to join friends. You can receive coupons for free, and have the opportunity to experience the top NMN imported from the United States for free!
Can NMN help fight COVID-19? reference video
As COVID-19 sweeps cities with a pneumonia-like disease that infects hundreds of millions of people around the world, scientists are searching for safe and effective treatments. Gerontologists, scientists who study the biology of aging, believe that aging-targeted therapies may offer a new perspective on the pandemic.
Statistics show that COVID-19 disproportionately affects older adults . About 13.4% of patients aged 80 or older died from COVID-19, compared with 1.25% and 0.06% of patients in their 50s and 20s, respectively. Age is the most important risk factor associated with death from COVID-19 , according to a recent Oxford University study analyzing 17.4 million UK adults . Other risk factors include being male, uncontrolled diabetes and severe asthma.
Given that the virus is harmful to the elderly, some geriatricians claim that treating "aging" may be a long-term solution to protecting the elderly from COVID-19 and other future infectious diseases. Although more research is needed, a recent study lists NAD+ boosters such as NMN and NR as one of the potential treatments. Other scientists have also hypothesized that older adults may benefit from NAD+'s longevity effects and prevent fatal overactivation of an immune response called a cytokine storm, in which the body attacks its cells instead of the virus.
NAD + is used in the fight against the coronavirus, which weakens our bodies, according to recent research. NAD+ is essential for innate immune defense against viruses . The study's researchers are trying to assess whether NAD+ boosters could help humans overcome the pandemic.
While scientists are racing in the lab to find a cure for COVID-19, doctors on the front lines have opted not to turn to innovative technologies. As a last resort, Cedars Sinai Medical Center physician Robert Huizenga injected patients with an NMN cocktail to quell the cytokine storm caused by COVID-19. The NMN cocktail reduced the patient's fever and inflammation levels within 12 hours . reference video
During the pandemic, NMN has received increasing attention for its role in maintaining the balance of the immune system, which could be a possible treatment for the cytokine storm caused by the coronavirus. Preliminary studies have shown some positive results, and while a cure is not guaranteed, many scientists and doctors believe the effects of NAD+ boosters on COVID-19 are worth studying.
Why can NMN fight COVID-19? Can NMN boost immunity?
Based on two research papers published in September 2020 on nmn's ability to enhance immunity and treat patients with COVID-19, the content is as follows: For detailed research information, please click NMN COVID-19
(1) Raising NAD+ levels can enhance the immune response to COVID-19 infection.
NAD+ is involved in a variety of cellular responses to generate energy and maintain cellular health, including immunity to viral infections. Research confirms that cellular NAD+ levels decrease with age, and that NAD+ levels that decrease with age can adversely affect immune responses to infections, including responses to COVID-19. The mortality rate from COVID-19 increases with age, and is more than 14% for people over 80, suggesting an age-related dysfunction of the immune system.
In a study published in the Journal of Infection and Public Health, scientists from Bahrain detailed the molecular level of NAD+'s impact on immunity to COVID-19. The researchers noted that COVID-19 infection causes cellular NAD+ levels to be depleted , and restoring NAD+ levels could reduce the severity of the body's immune response to infection to improve outcomes in COVID-19 patients .
(2) COVID-19 (coronavirus) patients improve with NMN cocktail.
Huizenga published a study in which he used a cocktail of NMN to treat nine elderly people with an average age of 65 years old who were infected with COVID-19 and had other medical conditions (comorbidities), two of whom had diabetes , five had prediabetes, two had severe heart disease, three were taking medication for high blood pressure, and six had a body mass index that classified them as overweight. All nine patients had fever, cough and lethargy, which made them mostly bedridden. Loss of smell (anosmia) in 6 of 9 patients and diarrhea in 5 of 9 patients.
The patients were experiencing symptoms of COVID-19 disease when Huizenga started giving them the NMN cocktail, starting the dosing within 5 to 34 days of the onset of COVID-19 symptoms. Four of the nine patients were critically ill with deteriorating oxygen saturation levels, but the NMN cocktail caused rapid clinical improvement, including fever reduction within two to three days. Importantly, no patients required intensive care after treatment .
For details, please click NMN COVID-19
What are some ways to increase NAD+ levels? For more ways to become younger, please click here Fountain of Youth
(1) Fasting or reducing calorie intake, better known as calorie restriction, has been shown to increase NAD+ levels and Sirtuin activity. In mice, calorie restriction-induced increases in NAD+ and sirtuin activity have been shown to slow the aging process. Although NAD+ is present in some foods, its concentration is too low to affect intracellular concentrations. Taking certain supplements, such as NMN, has been shown to increase NAD+ levels.
(2) Intake of the correct amino acids: try to replace animal protein with plant protein, and do not consume too much red meat.
(3) Activation of longevity genes through exercise, benefits including lengthening of telomeres. Promotes the production of new capillaries to deliver more oxygen to cells. Enhance mitochondrial activity and consume oxygen to produce more energy. While many types of exercise have positive health benefits, only high-intensity interval training (HIIT), which increases heart rate (by 70-85%) and breathing rate, activates a higher number of health-promoting genes. The effect is better.
(4) Expose the body to uncomfortable low or high temperatures , such as ice swimming, cryotherapy, high temperature ovens, etc.
Further reading: For more ways to become younger, please click here Fountain of Youth
NMN news is constantly reported in Taiwanese media, especially in 2021, NMN advertisements can be seen on shopping platforms and even news channels. Can you buy with confidence?
As mentioned in the previous question, what should be paid attention to when purchasing? Even if NMN is reported by the news media, it is actually found that there is a situation of implantable marketing. Therefore, it is absolutely necessary to carefully check the manufacturer, NMN origin, NMN content, NMN purity, NMN activity, etc. The label must be clear , not just NMN. Extract. Of course, there must be certification checks by government agencies, such as GMP, cGMP, FDA, NFC natural food certification, etc., to be guaranteed. Especially if you buy NMN on the Internet, you should be careful. Most of the NMN you see on social media advertisements are fake, and you must rely on professionals to distinguish them to avoid being deceived. (please click here to experience NMN immediately)
The latest research results of NMN from 2020 to 2021:
Since Professor David Sinclair published a groundbreaking paper on the reversal of aging by nmn in 2013, the dazzling halo and efficacy of nmn have been continuously confirmed and hundreds of papers have been published. As time progresses, more and more human clinical validations and the latest research results have been published. If you want to know more, please click NMN News! ( NMN news )
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How does NMN prevent cancer? NMN can activate NK cells
An important factor leading to cancer or the evolution of age-related diseases is the decline of immune function, and the main reason is that the activity of immune NK cells decreases with age. According to the latest research published on September 27, 2021, NMN can restore and activate NK cells without increasing the number of NK cells , so as to enhance immunity and prevent the formation of cancer cells to maintain tissue health.
NK cells are a kind of human immune cells, which are called natural killer cells (Natural killer cells, NK), belonging to the vanguard of the immune system, is the first line of immune killing. NK does not need to receive special instructions from the immune system, nor does it need the cooperation of other cells, it can recognize and eliminate aging, tumor or virus-infected cells by itself. NK cells are usually dormant and their activity decreases with age. Once activated, they infiltrate tissues, secrete perforin and necrosis factor, and attack tumor cells and virus-infected cells.
Okumura and other scientists at Juntendo University in Japan, published in Biomedical Research on September 27, 2021, demonstrated that mice treated with NMN restored the ability of NK cells to eliminate malfunctioning cells. It is worth noting that the result of enhanced NK cytotoxicity is not from an increase in the number of NK cells, but from an increase in the ability of NK cells to destroy cancer cells. These findings support that NMN supplementation can reduce the accumulation of precancerous and virus-infected cells, thereby improving NK cell immunity and overall tissue health without worsening as people age. Links to References
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NMN side effects? NMN carcinogenic? Or cancer prevention?
NMN is the first serious scientific research achievement in the world that has been rigorously scientifically verified to significantly reverse aging, prolong life, and prevent cancer. But there are rumors on the Internet that supplementing NAD+ may cause cancer?
In response to people's concerns about the health and safety of NMN, scientists from the Japan Center for Human Diseases and Health have conducted a large number of experimental studies on whether NMN is carcinogenic or anti-cancer. According to those self-media reports, scientists used NMN as experimental specimens, and divided laboratory mice into two parts, one was supplemented with normal doses of NMN, and the other was supplemented with large doses of NMN. Through research, it is found that the growth of cancer cells is related to senescent cells, because the increase of senescent cells promotes the release of inflammatory factors, and inflammatory factors stimulate tumor cells, thereby promoting the growth of cancer cells . The increase of senescent cells is related to the amount of NMN supplementation. The experiment found that mice with cancer cells, those mice with extreme supplementation of NMN more than 10 times the normal dose, had an increase in cancer cells in their bodies. However, in mice supplemented with normal doses, not only no obvious cancer cell growth was detected, but the mice also showed signs of rejuvenation, and some common diseases associated with age were also greatly improved.
Years of research have shown that the root cause of cancer is the mutation that occurs after gene damage and the weakening of the body's own repair genes. When cells repair genes, they need to consume the coenzyme NAD+ to support the self-repair of genes. If the level of NAD+ is low and damaged genes cannot be repaired in time, it may develop into cancer . However, NMN can increase the level of NAD+, improve the activity of NAD+, and accelerate gene repair, which can effectively prevent cancer.
Blood tests have been carried out since 2017. Through a large-scale experiment that lasted for three years, it was found that the longevity gene activity value of the human body increased by about 1.2 numerical points on average after ingesting NMN for three consecutive months. The significance of the human longevity gene activity value is that for every 0.5 numerical point increase in the average value, the possibility of death within 7 years due to age-related diseases such as cancer or stroke will be reduced by 50%.
It can be seen that NMN not only does not cause cancer, but also has the special effects of preventing cancer, curing cancer, curing diseases, strengthening the body, and prolonging life .
Further research has found that by taking NMN, it has a good therapeutic effect on most diseases and lifestyle diseases that the elderly are susceptible to, including preventing cancer, preventing cardiovascular and cerebrovascular diseases, preventing liver disease, improving diabetes, and improving arteriosclerosis. , inhibit middle-aged fat, greatly reduce blood sugar, treat Alzheimer's disease, increase bone density, early recovery of fractures, etc., all have a good effect.
At present, there are many anti-aging molecules or technologies being studied around the world, but only NMN technology has the highest recognition in the scientific community. Considering factors such as safety, efficiency, applicable groups, taking methods and price value, other anti-aging products cannot be compared with NMN.
Especially in terms of safety, Professor Hiroshi Ito of Keio University School of Medicine, Professor Kazuo Tsubada of Ophthalmology, Professor Masato Yasui of Pharmacology, Professor Hiroyuki Okano of Physiology, and Professor Shinichiro Imai of Washington University School of Medicine and his For the first time, colleagues demonstrate that animal studies show that NMN increases the levels of nicotinamide adenine dinucleotide (NAD+) present in various organs and inhibits aging-related diseases. At the same time, studies on human use showed that the research team conducted a clinical study on 10 healthy men and determined that NMN can be safely used in humans, and that NMN has obvious effects on the prevention and treatment of age-related diseases . The research results were published in the Endocrine Journal on November 2, 2019.
The experimental research of so many famous scientists and scientific research institutions has made us full of confidence in the prospect of NMN technology and its products in the prevention and treatment of various diseases such as cancer. The special effect of Shouyannian further deepened the impression.
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NMN does not cause cancer, but can also prevent cancer. Does it help cancer patients?
According to a paper published in 2021 : (Reference link 10.1158/0008-5472.CAN-20-3290)
1. Nicotinamide mononucleotide (NMN) prevents chemotherapy-induced brain cell and cognitive dysfunction.
Cancer itself is a scary thing, and getting treatment is even more painful. Chemotherapy takes a heavy toll on the body, and chemotherapy can deleteriously alter brain function similar to advanced aging. Reduces brain cell growth, branching and replication, and increases neuroinflammation and memory dysfunction. Notably, chemotherapy also accelerates biological aging and possible cognitive decline and leads to various toxic effects such as cognitive impairment, which has become a major medical problem.
In an article published in Cancer Research, researchers demonstrate that chemotherapy reduces levels of the important bioenergy molecule NAD+ in adult mouse brains and human brain cells. But increasing NAD+ levels via NMN administration prevented cognitive dysfunction in the brain caused by chemotherapy (cisplatin) at the level of individual cells and tissue structures. Importantly, the beneficial effects of NMN do not interfere with the antitumor efficacy of chemotherapy (cisplatin) without any adverse effects on tumor growth and the antitumor activity of cisplatin, ensuring that NMN is a safe and effective compound for the treatment of Chemotherapy-induced cognitive impairment . ! (For more information, please click NMN chemotherapy)
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Why NMN can enhance athletic ability? Reduce muscle loss?
We know that athletic ability is closely related to bones and muscles, and muscles are very closely related to blood vessels .
Vascular endothelial cells maintain the health and growth of blood vessels, the blood that delivers oxygen and abundant nutrients to organs and tissues. But with age, these endothelial cells gradually age, blood vessels shrink , new blood vessels cannot form, and blood flow to most parts of the body gradually decreases. Among them, the muscle has a greater impact, which will cause the muscle to gradually atrophy. When our muscles become less and less, of course, we have no strength to exercise to promote the growth of new blood vessels, forming a vicious circle.
According to Professor David Sinclair, two key factors in the interaction between blood vessels and muscles are the longevity proteins NAD+ and sirtuin1. NAD+ enhances SIRT1, thereby maintaining normal communication between muscle and blood vessel cells. But both NAD+ and SIRT1 decline with age. This leads to the inability of cells between muscles and blood vessels to communicate. In Professor David Sinclair's research, a group of 20-month-old mice (roughly equivalent to 70 years old in humans) were given NMN, a compound ubiquitous in humans that can increase NAD+ The increased levels of sirtuin1, in turn, enabled these aging mice to have better endothelial function, return to normal capillary number and density, and significantly increase muscle blood flow, preventing muscle loss . What's most striking? Their exercise capacity was greatly improved, in fact, in older mice treated with NMN, their exercise capacity increased by 80% .
Since this function of NMN can be used to improve the muscle atrophy of astronauts (astronauts lack of exercise due to weightlessness) and resist radiation. NASA also awarded the discovery team the David Sinclair iTech Award.
In addition to the above studies, there are also two latest NMN human body measurement papers: ( For detailed research, please click NMN to improve exercise ability)
(1) NMN improves muscle function and mobility in men over 65 :
On June 9, 2021, the University of Tokyo published a paper in the journal Research Square that oral administration of 250 mg of NMN daily significantly increased NAD+ levels and improved muscle performance in men over 65 years old . The study's results add to more evidence that the healthy aging benefits seen with NMN in animals such as rodents translate to humans. It also demonstrated that 250 mg/d NMN supplementation in healthy elderly men over 12 weeks was safe, well tolerated, and significantly increased NAD+ and NAD+ metabolites in whole blood. Additionally, NMN can improve muscle strength and performance. Therefore, long-term oral NMN may be an effective strategy to prevent age-related muscle diseases.
(2) NMN can enhance the exercise endurance of runners. NMN supplementation improves endurance performance in middle-aged athletes by increasing aerobic capacity :
Guangzhou University, China, 2021/07/08 Paper published in the Journal of the International Society of Sports Nutrition: NMN enhances exercise endurance performance in runners .
Evaluation method: A six-week randomized, double-blind, placebo-controlled clinical trial was conducted with 48 young and middle-aged amateur training runners in a running team. Participants were randomized into four groups, each consisting of ten male participants and two female participants: low-dose group (300 mg/day NMN), medium-dose group (600 mg/day NMN), high-dose group (1200 mg/day NMN) and control group (placebo). Each training time is 40-60 minutes, and runners train 5-6 times a week. Cardiopulmonary exercise testing was performed at 6 weeks to assess changes in runners' oxygen uptake and aerobic capacity. (Oxygen uptake capacity: The body's ability to absorb oxygen and deliver it to tissues. Aerobic capacity: The ability of muscles to use oxygen from the heart and lungs to produce energy is an important measure of exercise capacity)
Research conclusion: NMN increases the aerobic capacity of the human body during exercise training, which proves that NMN can improve the oxygen utilization rate of skeletal muscle, improve exercise ability and muscular endurance more than exercise alone . The researchers examined whether NMN had any adverse effects on runners. Importantly, none of the runners experienced any adverse physical events at the given dose. They found no abnormalities in cardiac examinations (electrocardiograms) or exercise tests, suggesting middle-aged adults can safely take doses up to 1,200 mg/day.
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Can NMN make skin look younger and more beautiful?
Humans are visual creatures, and the subconscious is fond of beautiful things. Most people must also be very concerned about their appearance. In addition to the body appearance (NMN can lose weight, please click the link) , the most important thing is of course the skin, and the skin is most afraid of aging, the first type of aging is natural aging, usually the changes brought about by natural aging are between 30 to 30 years old. It begins to appear during the age of fifteen, including the reduction of hair follicles, the reduction of sebaceous glands, the loss of blood vessels, fat and collagen. In the past, natural aging could not be remedied, but the new science of NMN can delay or even reverse aging. The second is exogenous aging, which is derived from external environmental reasons. Such as ultraviolet light, staying up late, smoking, or excessive sugar intake. This is also the direct killer of premature aging of young skin problems, the most important of which is photoaging.
Everyone who loves beauty knows that sun protection is very important . From the perspective of cell science, the laboratory of DHC Corporation in Japan published a study in the Journal of Photochemistry and Photobiology on June 12, 2021, showing that skin exposure to the sun causes UV damage The balancing act of activating NAD+ synthesis and NAD+ depleting enzymes will eventually severely deplete NAD+ levels, triggering stagnant skin cell proliferation and dysfunction, leading to aging . However, supplementing NAD+ precursor molecule NMN can restore the ability of cells to recover from UV damage and restore the skin to a youthful and energetic state. Therefore, supplementing NMN can not only delay the natural aging of the skin, but also increase the skin's ability to recover after photoaging, making the skin younger. pretty . (click for detailed research)
How does NMN evaluate? How does NMN buy? How does NMN price compare?
The latest NMN buying guide in the second half of 2021
There are so many NMN products and NMN brands on the market, and even many counterfeit products. How to choose and how to evaluate them so that you can buy the most suitable NMN products with the highest CP value? Based on long-term observation and professional evaluation, the following 5 steps are recommended, and you can buy the most effective NMN brand with confidence.
The first step is to select the country of production:
Since NMN is the latest high-tech product, it is very important to extract technology and formula. Therefore, it is necessary to prioritize which country has the strongest R&D energy in the biotechnology industry. According to OECD (Organization for Economic Cooperation and Development) statistics, the global biotechnology patent ranking, biotechnology research and development The strongest energy is the United States , followed by Japan, Germany, Canada, the United Kingdom, France and other medical powers, of which the United States is far ahead.
In addition, according to the three internationally recognized top academic journals "Science" (Science), "Nature" (Nature), "Cell" (Cell), the country with the most NMN-related papers published is still the United States .
Finally, review the published results of nmn research by academic and medical institutions. For example, the main inventor of NMN, Professor David Sinclair of Harvard Medical School, the main research institutions are also in the United States .
Therefore , the United States is the best choice for NMN production .
The second step, choose the brand:
That is to filter 5-10 kinds of NMN brands produced locally in the United States, and put them in the pocket list first!
It is a very difficult and time-consuming task to select a brand, and the screening criteria should be prioritized from the following aspects:
1, Whether the products of this brand can be independently developed and produced ? After all, NMN is a new generation of health care products in the past year. If it is not independently developed and manufactured, its performance and quality cannot be guaranteed. Moreover, if it is a brand that is contracted by other factories, the supply and quality of products may also be lower. Difficult to stabilize.
2, Investigate the establishment time of the brand. If the brand is more than 20 years old , it means that it has a certain strength, and it was not established solely for NMN business opportunities, and can be included in the consideration list.
3. For formula rights and patents , if there are more than 3,000 formula rights and patents, it means that it has certain research and development capabilities, and it can be included in the priority list.
The third step, look at the product formula
If you don’t want to buy fakes, you need to carefully observe this step.
In terms of the ingredients of the product formula, at least on the label and information on the bottle body, the following information must be disclosed:
1. NMN content : Because Taiwan's regulations on NMN are not perfect. Therefore, there are many product names on the market with the big "NMN", but in fact, if you look closely, there is no NMN in the ingredients, so you need to recognize the label . The example of the qualified label is as follows. -NMN is an ingredient , β stands for active NMN, and the content must also be marked . Of course, if it contains other ingredients, it must also be clearly marked.
Qualified bottle NMN label (example)
2. NMN purity and activity : It is best to be close to 100%, but most manufacturers do not have it on the bottle, so it is necessary to go to the official website of the brand or the website of a qualified distributor to confirm, and also confirm whether there is a third-party impartial unit. The purity inspection report .
3. Compound NMN : If you add resveratrol , it will be even more powerful! According to the research of Professor David Sinclair of Harvard University, NMN works best when paired with resveratrol, NMN provides fuel for the longevity gene Sirtuins; resveratrol activates Sirtuins independently. A combination of the two is more effective than a single formula. Because resveratrol is the #1 Sirtuin stimulant. Resveratrol + NMN is the most powerful anti-aging combination in the world.
4. Of course, there are other more compound ingredients on the market, which can be judged based on the information disclosed by the manufacturer.
5. Finally, it is necessary to confirm the requirements of the storage environment . Some NMN formulations are unstable under high temperature environments, which may cause NMN degradation, resulting in reduced efficacy. Therefore, it is necessary to confirm the storage environment. In addition, the packaging should try to choose opaque dark bottles to maintain the stability of NMN.
6. 最後還有一個重點，依據科學實驗，NMN在長時間（2個月以上）潮濕的環境下，會發生降解的情況，因此對於NMN包裝防潮能力也是評估重點，尤其在台灣海島型氣候，高溫潮溼的狀況，此點就更加重要了！
The fourth step, international certification
Because NMN is too novel, no matter how a lot of information is evaluated, there may be omissions or unknown places. Therefore, if there is an international certification check, it will be more reassuring. For the relevant international certification of NMN, it can be divided into 3 levels: Level 1: necessary certification. Level 2: Certification with substantial bonus points. Level 3: Additional points for certification.
Level 1 certifications include : FDA and GMP , brands without these two certifications can be ignored.
FDA is the English abbreviation of US Food and Drug Administration. It is an international medical review authority, authorized by the US Congress, the federal government, and the highest law enforcement agency specializing in food and drug management. Foods, drugs, cosmetics and medical devices certified by the FDA are safe and effective for the human body.
GMP American Good Manufacturing Practice Certification - GMP (Good Manufacturing Practice) is Good Manufacturing Practice, which is a necessary certification for excellent manufacturers.
Secondary certifications , including cGMP , USP , PDR : buy with confidence with these certifications
cGMP US Pharmacy factory certification - the abbreviation of the English name Current Good Manufacture Practices. Stricter than GMP management, it requires verification in the whole process of product production and logistics. cGMP can be said to be the international leading pharmaceutical production management standard.
USP (United States Pharmacopeia), the United States Pharmacopoeia Commission is a non-profit scientific research organization. Considered to be the world's high-level quality standard, the standards of the US Pharmacopoeia are not only the standards recognized by the US law, but also the standards recognized and adopted by manufacturers and regulatory agencies in more than 140 countries around the world. When a product is certified by the US Pharmacopoeia, it means that it has been Meet American and world quality standards.
PDR American Physician's Guide to Medication - PDR is an essential drug collection for American doctors. All prescription drugs collected by PDR must be certified and approved by the FDA. Relying on it, physicians can accurately query drug information, prescribe more accurately, ensure drug safety and avoid side effects. To be selected into PDR products, 3 must be done: 1. The product must be truly effective 2. It must be manufactured with pharmaceutical grade standards 3. The nutrients must be decomposed and absorbed within 45 minutes. Further reading: Why is it so important for NMN to have PDR certification?
Three-level certification, with these certifications, you can add points to the brand, such as USDA ORGANIC US organic certification, EU organic certification, organic certification from various countries, NSF certification of the National Sanitation Foundation, HALAL certification, MSDS raw material safety instructions...etc.
Fifth step, other matters
The most important ones are NMN price, NMN purchase channel, NMN product guarantee, and NMN after-sales service.
NMN price :
Due to the complex factors such as compound, unilateral, and purity, these can be temporarily excluded, and simply converted into unit NMN price for comparison, and then comprehensively judge after a bottom. For example: Assuming that a bottle of 30 capsules of NMN is priced at 4,000 yuan per capsule of 300mg, then each 1mg of NMN=4000/30/300=0.44 yuan
NMN purchase channel:
Unless a brand has been selected, and the brand happens to be sold on an e-commerce platform, try not to buy it on e-commerce platforms such as amazon, shopee, etc., because a lot of NMN information on these platforms is insufficient to evaluate. At present, well-known brands are mostly purchased online in the cross-border e-commerce model.
NMN product guarantee refers to whether there is product liability insurance and other guarantees!
NMN after-sales service is also very important. Because everyone's situation after using NMN is different, if you encounter any problems in use, such as physical reaction, timing of use, amount of NMN usage, etc., you need a professional to provide consultation and help answer.
NMN purchase requires professional evaluation and judgment. Do you know the method but don’t have time to do your homework? It's ok! Please click the button below to get the most detailed comparison table of the five recommended NMN brands for free!
In the face of post-epidemic life, improving immunity is the key, especially the Omicron variant virus is coming, are you ready? Don't worry, NMN will be your fastest, safe and effective secret weapon!
Going back to the best state when you were young, freezing age and reversing age is no longer a distant dream. You can also enjoy the magical technology of NMN as easily as the rich people!
Traditional direct selling has declined, and cross-border e-commerce is the trend. With NMN's latest blue ocean market, it will detonate the biggest business opportunity in this century! No matter where you are in the world or what language you are in, you can have it right away with just a few simple steps online or in person!
The gap in information in the 5G era is the gap between health and wealth! If you fail to keep up with the trend, you will be abandoned by the trend. Instead of having doubts in your heart, it is better to act now to create change!
NMN Lazy Bag NMN FAQs What to pay attention to when buying NMN
1. What is NMN? ( For more information about NMN, please click the magic NMN )
NMN is the abbreviation of Nicotinamide mononucleotide, with a molecular weight of 334.2192. It is an inherent substance in the human body and is also rich in some fruits and vegetables. In the human body, NMN is the precursor of NAD+, and its function is embodied by NAD+. NNM and NAD+ metabolism are linked.
2. What is the function of NMN? ( For more information about NMN, please click the magic NMN )
(1) Reverse human aging; (2) Eliminate skin wrinkles (3) Significantly improve cardiovascular system diseases (4) Long-term use can prolong human lifespan. All in all, NMN can significantly improve various chronic symptoms caused by aging in humans and fundamentally fight aging.
3. Why can NMN reverse aging? ( For in-depth understanding of NMN, please click the magic NMN )
NMN is the only cytokine with anti-aging function that has been proven by the three top international academic journals Science, Nature, and Cell. It can activate all 7 anti-aging proteins known to the human body, and comprehensively resist aging. It is currently known scientifically. The most comprehensive and powerful cellular anti-aging factor is considered to be the substance most likely to control human aging at this stage.
4. Is it safe to take NMN?
Taking NMN is safe and has no side effects. NMN itself is a naturally occurring substance in the human body, and it also exists in many foods. It is purely natural and harmless. Studies have confirmed that NMN supplementation does not affect the activities of various enzymes in the supplementary synthesis pathway. After oral administration of NMN, it has no effect on the activities of various enzymes in the supplementary synthesis pathway, such as NAMPT, PARP, and NMNAT, which directly changes the level of NAD+ in the body. Various NMN human clinical trials are also continuously being published, and the published human clinical tests have confirmed that it is safe without any side effects. For the clinical test content, please click NMN News.
5. Why is NMN called "the elixir of immortality"?
Dr. Paul F. Glenn Center for Biological Mechanism of Aging at Harvard University found that NMN reversed aging: Mice in their 60s who were in their 60s took NMN-containing water for a week, their body reached their 20s, and the mice taking NMN had a 20-year lifespan. %. Since then NMN has been known as the "elixir of life". The powerful "rejuvenating" effect of NMN comes from its three mechanisms: activate the longevity protein Sirtuins1~7, activate the DNA repair enzyme PARP, and activate the immune regulation loop ADP ribose synthase.
6. Is NMN a concept hype?
NMN is indeed the first serious scientific research achievement in the world that has been rigorously scientifically verified to significantly reverse aging and prolong life. It was initially discovered by the laboratory of David Sinclair at Harvard University in 2014.
7. Is NMN really that magical? ( For in-depth understanding of NMN, please click the magic NMN )
In the 2013 top international academic journal Cell, David Sinclair's lab found that supplementing NAD+ precursor NMN in 22-month-old mice could reverse mitochondrial function in their muscles back to 6-month-old mice. The level is equivalent to restoring the age of human beings from 60-70 years old to 20-30 years old. Compared with ordinary white mice, these experimental mice can burn fat for energy, improve metabolism, and maintain youthful muscles even when they are older. The amount of tears and bone density and the number of immune cells increased, and there were no obvious side effects.
8. Can NMN really survive?
Harvard Medical School professor David Sinclair's team published a research article stating that NAD+ is a substrate of the DNA repair protein PARP1 and an activator of the longevity gene SIRT1, which plays a key physiological function. However, in the process of aging, the content of NAD+ will decrease rapidly, which directly leads to a significant decrease in the activity of SIRT1, which affects mitochondrial function and reduces the power of the "cell's power plant", which leads to aging . This study provides a good explanation for the relationship between aging and NAD+. Numerous scientific and experimental studies have consistently confirmed that maintaining sufficient NAD+ in cells and maintaining the energy of mitochondria in the "cell power plant" is the key to inhibiting aging , and NMN is the best supplement for NAD+.
9. Why does NMN take effect so quickly, does it contain hormones?
It does not contain hormones at all, and the effect is fast because the application of small molecule promotion technology enables the absorption of NMN in the body very quickly, and it is absorbed through the digestive system intact. It enters the blood in 2 to 3 minutes, and increases the NMN content in the tissue within 15 minutes. 90 % is absorbed by the blood, rapidly increasing the NAD+ level in the blood, liver and other organs.
10. Is there no effect if there is no obvious feeling after use?
Aging is a relatively slow process. The subjective feeling after taking this product is related to various factors such as age and health status, and important indicators such as the reduction of DNA damage and the decline of the aging speed are difficult to directly perceive, so there is no obvious feeling. Indicates no effect. Because the content of NAD+ in the human body gradually decreases with age, older people feel more obvious than young people. According to statistics, less than 2% of people feel no effect.
11. How much NMN do adults need to supplement each day?
Experiments have confirmed that a 70Kg adult should supplement 100mg~1000mg of NMN every day. Regarding the optimal daily dosage of NMN, based on the current (October 2021) clinical measurements of all human beings in the world, the range is from 100mg to 1200mg per day (2020 Irie.. et al., 2021 Liao.. et al., 2021 Yoshino.. et al), the measured results have no adverse effect on various physiological data of the human body such as temperature, blood pressure, cerebral blood flow, blood data or other forms of toxicity, etc., confirming that it can be administered safely and effectively metabolized in the body without any side effect. And according to the clinical measurement results, the larger the amount of use, the more obvious the effect of the experimental data. Therefore, it is recommended that the daily usage of NMN can vary from 100mg to 1200mg per day according to different conditions such as individual age and body!
12. Are there any adverse reactions to taking NMN?
Taking NMN does not have any adverse reactions. It is a natural substance, does not contain artificial chemicals and hormones, is safe, non-toxic, and has no side effects. It will not have a destructive effect on the human body's endocrine system and chemical balance.
13. Is eating NMN dependent?
There is no dependence on existing natural substances in the body.
14. What is the significance of NMN on physical health?
NMN is an important source of energy for cell life activities, which can prevent age-related physiological decline, improve type 2 diabetes, and prevent neurodegenerative diseases (Parkinson, Alzheimer's disease), etc.
15. Who is NMN suitable for? Can the elderly eat it? Can both men and women eat it? Can the three-high ethnic group eat it?
Everyone can eat. Especially for anti-aging, poor sleep quality, low immunity, easy fatigue, poor liver function, Parkinson's patients, stroke patients, Alzheimer's and other people, NMN has significant help.
16. Where is NMN produced?
All products on this website are produced in GMP and cGMP standard factories under the supervision of FDA registration in the United States, manufactured in the United States, and delivered directly from the factory, which ensures the high quality, safety and reliability of the products from the source.
17. At what age should I start taking NMN?
NMN can be supplemented from the age of 25. Before the age of 25, the loss of NAD+ in the human body is not obvious, and it is not necessary to supplement.
18. How can I guarantee that the NMN I bought is genuine?
All products on this website are shipped directly from the United States, including postage, tax, and customs clearance.
19. Is NMN taken orally or injected?
oral. No injection or thread embedding, the anti-aging effect can be achieved by oral administration, with no toxic side effects and no risk. Beautiful health, beautiful nature, beautiful safety, beautiful lasting!
20. What is the difference between NR and NMN?
NR can be converted into NMN, and then NMN can be used to increase the level of NAD+, but the effect of oral NR is not good. The scientific reason is that the conversion of NR is more nicotinamide, not the desired NMN, there is a rate-limiting enzyme, in Control this step, irreversible.
21. What is the relationship between NAD+ and NMN?
NAD+ cannot directly enter the cell and NMN is converted into NAD+ in one step in vivo. NR is first converted to NMN in vivo and then from NMN to NAD+.
22. What are the advantages of the NMN brand recommended on this website compared with other NMN products?
A: NMN recommended brand-1 (Wayal) American business Vio Wayal 40-year-old American cGMP pharmaceutical factory, precise detection + targeted prevention = combining natural nutrition & American pharmaceutical technology to create high-quality functional health food.
40-year-old American cGMP pharmaceutical factory, all products are 100% made in the United States, with advanced formula and quality assurance.
200,000+ feet of super-large factory building is enough to supply capacity
R&D team of more than 50+ scientists + medical scientists
With more than 20,000+ formula rights
Daily production capacity: 50,000+ bottle packaging lines, 6,000,000 tablets, 1,000,000 capsules, 3,000,000 soft capsules
Products are sold to more than 20 countries including the United States, Canada, Taiwan, Europe, China, Indonesia, Malaysia, Russia, Hong Kong, etc.
The company holds a number of exclusive formula products
More than 100 registered trademarks and patents
In cooperation with Harvard University, Yale University, Columbia University, Indiana University, Duke University, Tufts University, the products are used in clinical experiments and pathological treatment
In cooperation with Cincinnati Children's Hospital, the second-ranked in the United States, and the Cleveland Medical Center, a world-renowned medical institution, the products are used in clinical experiments and pathological treatment.
Products with up to 13 international certifications & multiple organic certifications
A number of products have been selected into the "American Physician's Guide to Medication PDR"
The product is safe and reliable, and the product liability insurance is up to USD 8.5 million.
5 complete high-tech compounds (β-NMN, resveratrol, coenzyme Q10, L-carnitine, NAC), exert the most complete benefits of NMN, completely repair and activate cells, keep cells young, and achieve the effect of reversing aging. (For NMN purchase, please click this link product-Wayal)
B: NMN recommended brand-2 (Tree Life) Tree Life American business tree of life Tree Life:
Vegan raw material patent, multi-party certification guarantees non-toxic and no side effects, high-purity (99.99%) and high biological activity (100%) NMN. Treelife NMN is blessed with three Nobel Prize-winning technologies and GMP high-standard production standards to ensure the best cost-effective products. Each capsule of Treelife NMN contains 100mg of resveratrol, which greatly enhances human NAMPT, accelerates enzyme activity, and can convert NMN into NAD+ to maximize efficiency. Each Treelife NMN capsule also adds 7 other compounds that are very good for the human body:
1. Resveratrol (100mg), anti-aging, anti-oxidation, remove free radicals and garbage toxins in the body, regulate blood sugar levels, activate cells, and enhance immunity. Reduce LDL (bad cholesterol) levels and increase HDL levels to prevent cancer.
2. Calcium L-aspartate (100mg) – a calcium supplement with added nutrients, which can effectively increase bone density, prevent osteoporosis, have a good lubricating effect on joints, relieve joint pain, etc.
3. Alpha Lipoic Acid (50mg) – Prevents diabetic neurological diseases, has antioxidant effects, inhibits nerve damage, scavenges free radicals, slows down aging, protects the liver, and has cancer prevention and anti-cancer effects.
4. Riboflavin B2 (10mg) - Can effectively promote development and cell regeneration, enhance vision, reduce eye fatigue, promote basic metabolism of the body, and have a good slimming effect.
5. Adenosylcobalamin-Coenzyme B12 (125mg) - Can effectively promote the formation and regeneration of red blood cells, prevent anemia, maintain the normal function of the nervous system, promote concentration, improve memory and balance.
6. Vitamin K (125mg) - Can effectively prevent osteoporosis, protect blood vessels and maintain cardiovascular health, help blood clotting, and help memory
7. Boron (1mg), boron is a bioactive trace mineral that the body cannot lack. It helps the metabolism of minerals such as calcium, magnesium and phosphorus. Boron also helps maintain bone strength and structural health. (For NMN purchase, please click this link product-Tree Life)
C: NMN recommended brand-3 (Calerie) Link to Calerie page
Cross-border e-commerce new direct sales
Legally landed in the Taiwan market
The world's top standard NMN products
6 sales product PDR certification
NMN 4Excelsior production company invested by Li Ka-shing
One-stop R&D, production and sales
23. Why do we say that preventing aging means preventing various diseases?
The commonality of all aging-related diseases is that the incidence increases with age. Like a torrent that comes and is stopped by a dam, once a dyke bursts somewhere, all other bodily functions begin to suffer. Even if one of them is cured, it will eventually be dragged down by various other complications, which is the short-board effect of aging. Conversely, if you prevent the process of systemic aging, you can indirectly delay the occurrence of many diseases. reference video
24. Can NMN boost energy?
NAD+ provides 95% of the energy for the human body through the tricarboxylic acid cycle, and NMN is the precursor of NAD+.
25. Can NMN boost immunity?
NAD+ is the only substrate for cyclic ADP ribose synthase, which primes the immune system.
26. Why NMN can effectively reduce the toxic and side effects caused by radiotherapy and chemotherapy?
In clinical treatment, many drugs will have toxic and side effects on non-targeted sites, especially in the course of radiotherapy and chemotherapy, chemotherapy drugs will cause damage to normal cells, resulting in damage to organ function. Experiments have shown that administration of coenzyme I can protect normal cells in the body, reduce neutropenia during radiotherapy and chemotherapy, improve radiotherapy and chemotherapy tolerance, and comprehensively reduce the toxic and side effects of radiotherapy and chemotherapy. Coenzyme I for injection directly increases the content of coenzyme I (NAD) in renal cells, reduces renal cell apoptosis, and alleviates renal toxicity caused by chemotherapy drugs such as platinum. NAD+ administration significantly attenuated synchrotron X-ray-induced DNA damage, which would provide a basis for coenzyme I combined with radiotherapy in the treatment of tumors. NMN is an effective precursor to supplement NAD+.
27. Is NMN resistant to radiation?
Harvard Medical School Ph.D. Professor David Sinclair won the iTech competition in 2017 for his solution to a biological problem - NAD+ precursor NMN can directly repair DNA damage caused by radiation exposure or aging. When mice were treated with NAD+ and nicotinamide mononucleotide (NMN), their in vivo cells' ability to repair DNA damage caused by radiation exposure or aging was improved. Because NAD+ precursor NMN can directly repair DNA damage caused by radiation exposure or aging, NASA also chose NAD+ precursor NMN to resist radiation. Radiation is not only a problem faced by astronauts. Many radiation-related practitioners abroad will actively supplement NAD+ to resist aging. For example, laboratory work, related researchers (hardware engineers), pilots, and flight attendants who are at risk of radiation , frequent travel trapeze, often exposed outdoor workers.
28. Why can NMN stimulate blood vessel growth and delay muscle atrophy?
In cell experiments, human and mouse endothelial cells were treated with NMN to enhance their growth ability and reduce cell death rate. In animal experiments, the researchers administered NMN to a group of 20-month-old mice (roughly equivalent to 70 years in human years), which normalized the number and density of capillaries and significantly increased blood flow to the muscles. , and the blood supply to the muscles was significantly higher than in mice of the same age that did not receive NMN.
29. Why does NMN prevent cancer?
NAD+ is the substrate of ADP ribosyltransferase or ribosyl polymerase (PARP). PARP is located in the nucleus of a variety of cells. When free radicals and oxidants cause damage to cells, the single strand of DNA will be broken, and PARP will be activated. The PARP utilizes coenzyme I (NAD+) as a substrate to transfer ADP ribosyl to target proteins while generating nicotinamide (Nam), which are involved in DNA repair, gene expression, cell cycle progression, cell survival, chromosome remodeling and gene stability and other functions. Studies have shown that PARP has a positive effect on the treatment of cancer, exerting a multifunctional role in various cancer-related processes, including DNA repair, recombination, cell proliferation or cell death.
30. Why NMN can enhance exercise endurance?
Vascular endothelial cells maintain the healthy growth of blood vessels, delivering oxygen and nutrient-rich blood to organs and tissues. But with age, these endothelial cells gradually age, blood vessels shrink, new blood vessels fail to form, and blood flow to most parts of the body gradually decreases. This dynamic is especially pronounced in muscles because they are highly vascularized and rely on large amounts of blood to function. David Sinclai, a professor at Harvard Medical School, has successfully reversed vascular atrophy and muscle atrophy in aging mice and enhanced their exercise tolerance using NMN, a synthetic precursor of two molecules present in the body.
31. Why is reversing vascular aging the same as restoring youthful vitality?
As the saying goes, vascular age reflects real age. Vascular aging can induce a series of diseases, such as heart and nerve diseases, muscle atrophy, wound healing disorders and general weakness. Reversing vascular aging is equivalent to restoring youthful vitality. reference video
32. Can NMN prevent neurodegenerative diseases (Parkinson's, Alzheimer's)?
Experiments have shown that NAD+ supplementation improves neuroprotection against traumatic brain injury, Parkinson's, and ALS, normalizes neuromuscularity, and delays memory decline. Alzheimer's disease exhibits reduced NAMPT and impaired neural stem cell differentiation, and after extremely high NAMPT activity or NAD+ supplementation, reduces the increase in beta-amyloid levels, via PGC-1α-mediated beta-secretase (BACE1) Degradation and induction of mitochondrial biosynthesis to improve Alzheimer's disease.
33. Can NMN relieve alcohol and protect the liver?
NMN promotes alcohol metabolism and enhances the body's tolerance to alcohol.
34. Can NMN protect eyesight?
NMN prevents photoreceptor cell degeneration and restores vision, saving retinal disorders.
35. Can NMN protect hearing?
NMN increases NAD+ levels in ear neurons and tissues, which may provide protection against trauma-induced hearing loss.
36. Why is NMN not recommended for pregnant and lactating women?
Because there is enough NAD+ in the fetus and newborn body, avoiding excessive supplementation will affect the natural and normal growth of the fetus and baby.
37. There are so many NMN brands on the market, NMN evaluation, NMN efficacy, where to buy NMN and other important issues, how to fully evaluate?
Because NMN's efficacy and research results are too powerful, it has the opportunity to replace most of the health food on the market, so many unscrupulous industry players, in the name of NMN, but sell products that do not contain NMN ingredients, because NMN health food is too new. , NMN has no regulations in Taiwan, causing many people to be deceived. Therefore, when evaluating NMN, choosing an NMN brand, and purchasing NMN, you really need to evaluate carefully. There are many precautions, so be sure to confirm it clearly. The NMN No1 website carefully selects brands, and is checked by the most credible American Physician's Guide to Medication, PDR, to provide you with a full range of guarantees. It is no longer just relying on Internet information. It is definitely one of the most reliable choices in the world. To know the NMN brand, please click this link (please click here to experience NMN immediately)
38. NAD+ is the key substance to reverse aging, why not directly supplement NAD+?
Taking NAD+ directly will not have the same effect as taking NMN. The reason is that even if NAD+ is taken orally, most of the NAD+ will be destroyed in the environment and digestive system, so NAD+ cannot reach the level of brain and blood. And NAD+ molecular weight is larger and its chemical properties are difficult to enter cells through the cell membrane. In addition, when NAD+ is directly injected into the blood vessels, abnormal glucose metabolism will be induced, which will cause the risk of onset similar to diabetes, so it is less suitable to use NAD+ directly.
After rigorous scientific research, as shown in the figure below, after using NMN, the precursor of NAD+ (red line), it can enter the blood in 10 minutes, be absorbed by body organs after 30 minutes, and be converted into NAD+ (blue line), providing systemic cells use! Therefore, using NMN is the most natural, safe and effective NAD+ supplement.
The latest NMN FAQ in 2021
What is NMN?
How is NMN different from other stem cell supplements?
Why not supplement NAD+ directly?
Will NMN have many side effects?
The latest NMN FAQ in 2021
Can NMN boost immunity against the COVID-19 virus?
Why NMN can enhance athletic ability? Reduce muscle loss?
Can NMN make people's skin younger and more beautiful?
The latest NMN FAQ in 2021
NMN | How to choose NMN｜The latest NMN buying guide in 2021| NMN brand| NMN comparison| NMN evaluation|
NMN is the latest revolution in the way of becoming younger across the century. There are a lot of brands on the market. How to choose NMN? Can the NMN endorsed by celebrities be bought? Through the detailed explanation of NMN brand, NMN comparison, and NMN evaluation in this episode, it is definitely the latest NMN buying guide in 2021. I have taken the NMN classroom-3 class and found the most cost-effective NMN price, and I guarantee that I can buy the best NMN with the highest CP value. !
The latest NMN FAQ in 2021
Is NMN a big bubble? | Latest NMN Industry Trend Analysis in 2021 | Health and Longevity Industry | NMN Blue Ocean Market | NMN Future Trends | NMN Business Opportunities
The words NMN have gradually appeared in people's lives. What will be the future trend of NMN? Is NMN a blue ocean market? Or a big bubble? Through the latest NMN industry trend analysis in 2021, we will know the relationship between NMN and the health and longevity industry, and know the future development of NMN as a reference for whether to invest in NMN business opportunities!
Featured Videos of the Week for November 2021
NMN | David Sinclair | Why does NMN need to be paired with resveratrol? | sirtuins longevity gene | anti-aging health food
Don't eat NMN indiscriminately, so as not to waste precious NMN, why do you say that? Click on the video to learn more and hear what Professor David Sinclair has to say!
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NMN安全性及NMN副作用，是所有想要使用NMN的人們最關心的問題！藉由2022年哈佛醫學院最新NMN人體臨床實測結果，也許可以提供給你參考！
此次NMN人體人體臨床，採用醫療等級的高標準來進行測試，具有指標性及權威性！
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隨著 NMN 一篇又一篇研究論文的問世，已經顛覆了人類壽命的想像，正式開啟了健康、長壽的大革命！但市面上NMN有8成是假的，你相信嗎？NMN購買注意事項有哪些呢？在網路上要如何選NMN品牌？這篇亞馬遜22個暢銷NMN品牌含量實測結果，將可幫助你買到純正的βNMN品牌！